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Morrow-Brooke syndrome

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An apparently infectious skin disease that resembles keratosis follicularis (Darier syndrome). At onset, erythematous follicular papules, which rapidly change into comedo and follicular cysts that later form large keratinised brown plaques, tending to become confluent. The eruption is usually generalized and symmetrical, involving the nape of the neck, the shoulders, the back, and the extensor surfaces of the extremities. The chief features are keratotic thickening of the skin with deep furrows and comedolike black plugs which later become large brownish papules, and sometimes coalesce. The skin becomes dry and rough. Fissuring of the tongue and leukoplakia are the principal oral manifestations. Outbreak in different world regions.


  • P. A. Morrow:
    Keratosis follicularis associated with fissuring of the tongue and leukoplakia buccalis.
    Journal of Cutaneous and Venereal Diseases, Chicago, 1886, 4: 257-265.
  • H. A. G. Brooke:
    Keratosis follicularis contagiosa.
    In his: International Atlas of Rare Skin Diseases, 1892, No. 7, plate 22.
  • H. Flegel:
    Gibt es eine Keratosis follikularis Morrow-Brooke?
    Det Hautarzt, 1964, 15: 595-598.

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