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Albright's syndrome II
Also known as:
Albright hereditary osteodystrophy
Associated persons:
Fuller Albright
Description:
This title has been used to exemplify the effects of failure of an end organ to respond in a normal way to is corresponding hormone. Deficiency of hormone is not a factor. The descriptive term had its origin from the appearance of female plumage in the tail feathers of the Sebright Bantam rooster. This peculiar derangement is due to a failure of normal response of the feathers (end organs) to the androgenic hormone.
Albright and associates first applied the term "Seabright Bantam syndrome" to an analogous clinical counterpart observed in the human. The clinical state was in every way identical to hypoparathyroidissm.
Symptoms and signs of this disorder are all those of Martin-Albright syndrome except that there are normal calcium and phosphate values and lack of related symptomatology. It occurs in a hypocalcaemic form and a normocalcaemic form. Patients with the hypocalaemic form exibit short stature and obesity, whereas those with the normocalcaemic form are usually taller and less obese. Etiology unknown. Probably inherited as an X-linked disorder.
Bibliography:
- F. Albright, C. H. Burnett, P. H. Smith, W. Parson:
Pseudo-hypoparathyroidism: an example of ”Seabright-Bantam syndrome”.
Endocrinology, Baltimore, 1942, 30: 922-932.
- F. Albright, A. P. Forbes, P. H. Henneman:
Pseudopseudohypoparathyroidism.
Transactions of the Association of American Physicians, Philadelphia, 1952, 65: 337-350.
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