The term refers to megaloblastic anemia with a superimposed infection and deficiency of vitamin C, observed in children. It is characterized by morphological and functional abnormalities in the blood and bone marrow. Weakness, palpitation, fatigue, shortness of breath, and pallor are the usual symptoms. Congestive heart failure may occur. It is treatable with the administration of folic acid.
- W. Zuelzer, F. N. Ogden:
Megaloblastic anemia in infancy : a common syndrome responding specifically to folic acid therapy.
American Journal of Diseases of Children, Chicago, 1946, 71: 211-243.
- W. S. Beck:
The megaloblastic anemias.
In W. J. Williams, E. Beutler, A. J. Erslev, M. A. Lichtman, editors: Hematology. 3rd edition, New York, McGraw-Hill, 1983, pp 434-465.