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Ham's test
Also known as:
Ham-Dacie acidified serum test
Ham-Dacie test
Associated persons:
Sir John Vivian Dacie
Thomas Hale Ham
Description:
The definitive test for diagnosing paroxysmal nocturnal heamoglobinuria (PNH). The red cells are tested for resistance to lysis during incubation with acidified fresh serum. Lowering of pH results in complement lysis of red cells with the PNH defect.
See also Crosby's test, under William Holmes Crosby, American physician, born 1914.
Bibliography:
- T. H. Ham:
Studies on the destruction of red blood cells.
Archives of Internal Medicine, Chicago, 1939, 64: 1271-1305.
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