A sequence of chemical reactions, occurring primarily in the liver, by which ammonia is converted to urea in mammalian tissue. The urea, far less toxic than ammonia, is subsequently excreted in the urine of most mammals. Also known as the ornithine citrulline arginine urea cycle, this cycle also serves as a major source of the amino acid arginine.
- H. A. Krebs, K. Henseleit:
Untersuchungen über die Harnstoffbildung im Tierkörper.
[Hoppe-Seyler’s] Zeitschrift für physiologische Chemie, Strasbourg, 1932, 210: 33-46.
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