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Allan-Herndon-Dudley syndrome

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An X-linked mental retardation/multiple congenital anomaly syndrome characterized by psychomotor retardation, long thin face, severe hypotonia, joint contractures, and hyporeflexia. Male. Normal at birth but for hypotonia. At 6 months inability to hold up the head. Retarded motor development, muscular atrophy. At more advanced age, joint contractures and hyporeflexia. X-linked inheritance suggested.


  • W. Allan, C. N. Herndon, F. C. Dudley:
    Some examples of the inheritance of mental deficiency; apparently sex-linked idiocy and microcephaly.
    American Journal of Mental Deficiency, Washington, 1943-1944, 48: 325-334.

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