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Criswick-Schepens syndrome

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A familial disease usually observed in otherwise healthy children, with symptoms similar to those in retrolental fibroplasia. Symptoms include slowly progressive ocular changes with posterior vitreous detachment, traction on the retina in all quadrants, snowflake opacities in the vitreous body, heterotopia of the macula with temporal traction, subretinal and intraretinal exudates occurring at the periphery, and localized retinal detachment. Inheritance is autosomal dominant.


  • V. G. Criswick, C. L. Schepens:
    Familial exudative vitreoretinopathy: a report of two cases.
    American Journal of Ophthalmology, Chicago, 1969, 68: 578-594.
  • Y. Li, C. Fuhrmann, E. Schwinger, A. Gal, and H. Laqua:
    The gene for autosomal dominant familial exudative vitreoretinopathy (Criswick-Schepens) on the long arm of chromosome 11.
    American Journal of Ophthalmology, Chicago, 1992, 113: 712 -713.

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