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Brown's ataxia (Sanger Brown)

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This hereditary ataxia described by Sanger Brown in 1892 is one of the unusual types collected by Pierre Marie in 1893. It is accompanied by numerous ophthalmic abnormalities and pathologic changes in several tracts of the spinal cord. Ptosis, squint, and diplopia are common symptoms. Retinitis pigmentosa, ophthalmoplegia, and optic atrophy is often present. Neurologic lesions are predominantly in the posterior column, Clarke's column, and spinocerebellar tracts.

See also Marie’s ataxia, under Pierre Marie, French neurologist, 1853–1940.


  • Sanger Brown:
    On hereditary ataxia, with a series of twenty-one cases.
    Brain, Oxford, 1892, 15: 250-282.

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