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Abercrombie's degeneration

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Disease picture in generalized amyloidosis occurring in a wide variety of acquired and hereditary disorders. It is characterised by deposition of amyloid between cells of various tissues and organs,

First described by Abercrombie. Later the German pathologists Rudolf Virchow (1821-1902) and Otto Lubarsch (1860-1933) concerned themselves with the disturbance. The terms «amyloid» and «amyloid degeneration» was coined by Virchow.


  • R. Virchow:
    Über den Gang der amyloiden Degeneration.
    Virchow’s] Archiv für pathologische Anatomie und Physiologie und für klinische Medicin, Berlin, 1854, 8: 364-368.
  • O. Lubarsch:
    Hyaline und amyloide Degeneration.
    Ergebnisse der allgemeinen Pathologie und pathologischen Anatomie der Menschen und der Tiere, Berlin, 1899, 4: 449-460.
  • G. G. Glenner, T. F. Ignaczak, D. L. Page:
    The inherited systemic amyloidoses and localized amyloid deposits.
    In: J. B. Stanbury, J. B. Wyngaarden, D. S. Fredrickson, editors: The metabolic Basis of Inherited Disease. 4th edition; New York, McGraw-Hill, 1978, pp. 1308-1339.

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