- A dictionary of medical eponyms

Bannayan's syndrome

Alternative eponyms

  • Bannayan-Riley-Ruvalcaba
  • Bannayan-Zonana syndrome
  • Riley-Smith syndrome
  • Ruvalcaba Myhre-Smith syndrome

Related people

A very rare familial disease with a predilection in males. It manifests with symmetrical macrocephaly without ventricular enlargement, mild neurological dysfunction, and postnatal growth retardation.

Description

A very rare familial disease with a predilection in males. It manifests with symmetrical macrocephaly without ventricular enlargement, mild neurological dysfunction, and postnatal growth retardation. Mesodermal hamartomas are present and most patients have discrete lipomas and haemangiomas. Associated disorders may include antimongoloid palpebral fissures, high-arched palate, joint hyperextensibility, pectus excavatum, strabismus, amblyopia, drooling, mental retardation, cerebral haemorrhage, and seizures. Inheritance is autosomal dominant.

D. Harris and William R. Smith, Oklahoma, in 1960 described a mother and four of her seven children with the trias of macrocephaly, pseudopapilledema, and multiple haemangiomas. G. A. Bannayan in 1971 described a single case with macrocephaly and multiple lipomas and haemangiomas. R. Ruvalcaba, S. Myhre, and David W. Smith, paediatricians, Seattle, in 1980 described two patients with macrocephaly, intestinal polyposis and spotted pigmentation of the shaft of penis.

Bibliography

  • Harris D. Riley, W. R. Smith:
    Macrocephaly, pseudopapilledema and multiple hemangiomata.
    Pediatrics, Evanston, Illinois, 1960, 26: 293-300.
  • G. A. Bannayan:
    Lipomatosis, angiomatosis, and macrocephalia: a previously undescribed congenital syndrome.
    Archives of Pathology, Chicago, 1971, 92: 1-5.
  • J. Zonana, et al:
    Macrocephaly with multiple lipomas and hemangiomas.
    Journal of Pediatrics, St. Louis, 1976, 89: 600-603.
  • R. H. A. Ruvalkaba, S. Myhre, D. W. Smith:
    Sotos syndrome with intestinal polyposis and pigmentary changes of the genitals.
    Clinical Genetics, Copenhagen, 1980, 18: 413-416.
  • J. H. Miles, J. Zonana, J. McFarlane, et al: Macrocephaly with hamartomas: Bannayan-Zonana syndrome.
    American Journal of Medical Genetics, New York, 1984, 19: 225-234.

What is an eponym?

An eponym is a word derived from the name of a person, whether real or fictional. A medical eponym is thus any word related to medicine, whose name is derived from a person.

What is Whonamedit?

Whonamedit.com is a biographical dictionary of medical eponyms. It is our ambition to present a complete survey of all medical phenomena named for a person, with a biography of that person.

Disclaimer:

Whonamedit? does not give medical advice.
This survey of medical eponyms and the persons behind them is meant as a general interest site only. No information found here must under any circumstances be used for medical purposes, diagnostically, therapeutically or otherwise. If you, or anybody close to you, is affected, or believe to be affected, by any condition mentioned here: see a doctor.