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Gull's disease

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An adult form of hypothyroidism characterized by decrease in sweating, cold hypersensitivity, dry and cold skin, gain of weight, easy fatigability, decrease in activity, progressive constipation, mental dullness, prolonged reflex time, carotinuria, and excessive and prolonged menses. Other symptoms may be deafness, thick speech, dizziness, headache, congestive heart failure, pernicious anemia, hypothermia, stiffness of joints and decreased libido. Females more frequently affected than males; insidious onset in middle age.


  • W. W. Gull:
    On a cretinoid state supervening in adult life in women.
    Transactions of the Clinical Society of London, 1873-1874, 7: 180-185.

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