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Passow's syndrome

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A syndrome of multiple congenital anomalies which is an association of Horner's syndrome with heterochromia iridis. Symptoms and signs (variable) include muscular weakness, trophic changes,; facial hemiatrophy; abducens (VI) and facial (VII) nerve paralysis, anaesthesia of first branch of trigeminal (V) nerve; myosis, heterochromia iridis, cervical rib symptoms, kyphoscoliosis, spina bifida, extremities malformations. Due to congenital lack of neural tube closure.

See also Bernard-Horner syndrome, or Cervical sympathetic paralysis syndrome, under Claude Bernard, French physiologist, 1813-1878.


  • A. Passow
    Okulare Paresen im Symptomenbild des “Status dysraphicus,” zugleich ein Beitrag zur Ätiologie der Sympathikusparese (Horner-Syndrom und Heterochromia iridis) sowie der Trigeminus Abduzens- unf Fazialisparese.
    Münchener medizinische Wochenshrift, 1934, 81: 1243-1250? Analogie und Koordination von Symptomen der Arachnodactylie und des Status dysraphicus (zur Frage der Wesensgleichheit beider Komplexe).
    Klinische Monatsblätter für Augenheilkunde, Stuttgart, 1935, 94: 102-103.

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