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Friedrich Theodor von Frerichs - bibliography

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German internist, born March 24, 1819, Aurich, Hannover; died March 14, 1885, Berlin, Germany.


  • De polyporum structura penitiori. Göttingen, 1843.
  • Untersuchungen über Galle in physiologischer und pathologischer Beziehung.
    Göttingen, 1845.
  • Commentatio de natura miasmatis palustris.
    Habilitation thesis, Göttingen, 1845.
  • Über Gallert- und Colloidgeschwülste. 1847.
  • Über das Mass des Stoffwechsels, sowie über die Verwendung der Stickstoffhaltigen und stickstoffreien Nahrungsstoffe.
    Archiv für Anatomie, Physiologie und wissenschaftliche Medicin, Leipzig, 1849.
  • Ueber Hirnsklerose.
    Archiv für die gesammte Medicin, Jena, 1849, 10: 334-350.
    First important account of multiple sclerosis. Frerichs' clinical account for the first time recognised remissions as a characteristic feature of MS. In addition, he described nystagmus as a symptom of the disease, this physical sign later being incorporated into the famous Charcot's triad. Frerichs also made a major contribution by providing the first medical description of mental disorders in MS, recognising the possible impact of the disease on cognitive and other higher functions of the brain.
  • Die Bright’sche Nierenkrankheit und deren Behandlung.
    Braunschweig, Friedrich Vieweg und Sohn, 1851. 286 pages.
    Frerichs divided the progression of renal disease into three stages: initial hypeamia, fatty infiltration and exudation, and organization leading to fibrosis and atrophy. This is one of the earliest works on kidney disease to incorporate histological appearances. However, Frerichs did not recognize the primary involvement of the glomerulus in what later became known as glomerulonephritis (Klebs's disease).
  • Klinik der Leberkrankheiten.
    2 volumes and atlas. Braunschweig, Friedrich Vieweg und Sohn, 1858-1861. 2nd and improved edition, 1861.
    English translation:
  • A Clinical Treatise on Diseases of the Liver.
    London: New Sydenham Society, 1860.
  • A Clinical Treatise on Diseases of the Liver.
    Translated by Charles Murchison, New York : W. Wood, 1879.
    Frerichs's classic monograph on diseases of the liver summarized the existing knowledge and included his own important work on the subject. The first description of progressive familial hepatolenticular degeneration, known as Kinnier Wilson's is in volume 2, pp. 62-64.
  • Ueber den Diabetes. Berlin, 1884.
  • U. Schwartz and E. Ritz:
    Glomerulonephritis and progression- Friedrich Theodor von Frerichs, a forgotten pioneer.
    Nephrology, Dialysis, Transplantation, Oxford, 1997, 12: 2776-2778.

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