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Adolphe Marie Gubler

Born 1821
Died 1879

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French physician and pharmacologist, born April 5, 1821, Metz; died April 20, 1879; Paris.

Biography of Adolphe Marie Gubler

As an adolescent,Adolphe-Marie Gubler concerned himself with botany during a stay at his uncle a military pharmacologist in Rocroy, near Paris. He studied medicine in Paris from 1841, and, at the initiative of Armand Trousseau (1801-1867), he became travelling companion to a young man who had become melancolic because of a duelling affair. In a bout of mania the young man had almost shot him in Milano. Because of his wounds, from which he was never completely to recover, Gubler had to spend almost a year in Milano.

Gubler became interne des hôpitaux in 1845 and obtained his doctorate in Paris in 1849. He then became pysician at the Hôpital Beaujon, in 1850 chef de clinique at the medical faculty and médecin de Bureau central des hôpitaux. In 1852 he received the prize of the Académie des sciences and became vice president of the Société de biologie, of which he had been a member since its founding in 1848/1849.

In 1849 Gubler wrote one of the first descriptions of syphilitic gumma of the liver and described the liver lesions in congenital syphilis. In 1853 he obtained his agrégé after defending his classic Thèse d'agrégation on the «Theories of the production of cirrhosis in the liver» and in 1856 published his first work on hemiplegia. The following year he drew attention to flushing of the cheekss in relation to pneumonia and popularised this sign which had been described earlier. He was one of the first to emphasise the importance of examining the patient’s urine, both chemically and microscopically, and drew attention to the significance of the presence of hyaline and granular casts. Gubler was the first to distinguish between haemotogenous and hepatogenous icterus.

In 1865 Gubler became a member of th Académie de médecine, and in 1868 was appointed professor of therapy at the medical faculty in Paris, remaining in that position until his death in 1879.

A cheerful individual, he was above all a clinical investigator who endeavoured to apply the most recent scientific advances to the treatment of his patients.

We thank Søren Nørby for correcting an error in our original entry.

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