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Ritta and Victor Stanescu
Romanian physicians.
Associated eponyms:
Maroteaux-Stanescu-Cousin syndrome
Recessive lethal chondrodysplasia.
Maroteaux-Verloes-Stanescu syndrome
A very rare syndrome where abnormal bone development starts early in life and is fairly severe but after a few years, the bones return to almost normal.
Biography:
Victor Stanescu was born in Bucharest, Rumania, in 1923, and received his M.D. from the University of Bucharest in 1949. After completing a residency in internal medicine and endocrinology, he was appointed Chief of the Department of Pediatric Endocrinology and Metabolic Diseases in Bucharest. During this period, several hundred children with growth disorders were referred yearly for diagnosis and treatment, and it soon became apparent that many of them did not have endocrine-related growth disorders, but probably primary diseases of the physis (osteochondrodysplasias).
To acquire a better understanding of physeal pathology, and to provide a basis for the diagnosis and classification of the chondrodysplasias, Stanescu developed a safe method for biopsy of the proximal tibial growth plate which avoided the secondary center of ossification and the danger of bone-bridge formation’. He then embarked on what has become a lifelong study ofthe histopathology of human osteochondrodysplasias#{176}’4’5. He found that the cytoplasm ofthe chondrocytes in some chondrodysplasias (that is, pseudoachondrodysplasia) was distended by peculiar large inclusions. However, the resolving power of the light microscope was inadequate.
Fortuitously, Dr. Ritta Stanescu, Victor Stanescu’s wife, has become an outstanding electron microscopist, who collaborates intimately with her husband. Due to her work, and that of others5, the peculiar inclusions within chondrodysplastic chondrocytes have been clearly visualized.
At the time of the publication of the article describing ”their” syndrome, Pierre Maroteaux, Victor Stanescu and Ritta Stanescu were affiliated at Hôpital des Enfants Malades in Paris.
Editorial:
- The Physis as an Interface between Basic Research and Clinical Knowledge.
The Journal of Bone and Joint Surgery. American Volume, 1984, 66: 815-960.
We thank Patrick Jucker-Kupper, Switzerland, and André Trombeta, for information submitted.
Bibliography:
- Histochemical and Histoenzymological Studies on the Growing Cartilage in the Turner’s Syndrome.
V. Stanescu, Marcella Pitis, V. Ionescu and C. Bona.
Acta histochemica, Jena, 1965, 20: 309-330.
- Histochemical and Cytoenzymological Studies on the Growing Cartilage in de Lange Syndrome.
V. Stanescu, C. Bona and V. Ionescu.
Acta histochemica, Jena, 1968, 30: 1-18.
- The Tibial Growing Cartilage Biopsy in the Study of Growth Disturbances.
V. Stanescu, C. Bona and V. Ionescu.
Acta endocrinologica, Copenhagen, 1970, 64: 577-601.
- Microchemical Analysis of Human Tibial Growth Cartilage in Various Forms of Dwarfism.
Victor Stanescu, Ritta Stanescu and J. A. Szirmai.
Acta endocrinologica, Copenhagen, 1972, 69: 659-688.
- Etude morphologique et biochimique du cartilage de croissance dans les osteochondrodysplasies.
Victor Stanescu, Ritta Stanescu and Pierre Maroteaux.
Archives francaises de pédiatrie, Paris, 1977, 34 (supplement): 1-80.
- Pathogenic Mechanisms in Osteochondrodysplasias.
Victor Stanescu, Ritta Stanescu and Pierre Maroteaux.
The Journal of Bone and Joint Surgery. American Volume, July 1984, 66: 817-836.
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