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Michael Melnick
American medical geneticist.
Associated eponyms:
Melnick-Fraser syndrome I
A very rare genetic disorder characterised by distinctive malformations of the head and facial area, with skin lesions and abnormalities of the eyes.

Melnick-Fraser syndrome II
A genetic disorder marked by different kinds of hearing loss, malformed ear pits, neck cysts and kidney problems.

Biography:
Michael Melnick is professor of genetics at the University of Southern California, Laboratory for Developmental Biology, Andrus Gerontology Center, Los Angeles, California.
We thank Andrey Azov for information submitted.
Bibliography:
- Michael Melnick and Ntinos C. Myrianthopoulos:
External Ear Malformations: Epidemiology, Genetics, and Natural History.
Book. A. R. Liss, 1979.
- Michael Melnick, Ronald Jorgenson:
Developmental Aspects of Craniofacial Dysmorphology: Proceedings of a Symposium Held June 1978 in San Francisco, California, and Sponsored by the Society of Craniofacial Genetics and the National Foundation-March of Dimes.
Book. A. R. Liss, 1979.
- Michael Melnick, David Bixler, Edward D. Shields:
Etiology of Cleft Lip and Cleft Palate: Proceedings of a Workshop Held at Airlie House, Virginia, Sponsored by the National Institute of Dental Research and the Society of Craniofacial Genetics.
Book. A. R. Liss. 1980.
- Michael Melnick, Tina Jaskoll and Harold C. Slavkin:
Corticosteroid-induced cleft palate in mice and H-2 haplotype: Maternal and embryonic effects. Immunogenetics, July 1981, 13 (5): 443-450.
- Michael Melnick, Edward D. Shields, Norbert J. Burzynski:
Clinical Dysmorphology of Oral-Facial Structures. 1982. 533 pages.
- Michael Melnick, Mary Marazita and Tina Jaskoll:
Corticosteroid-induced abnormality in fetal mice and H-2 haplotype: Evidence of a cytoplasmic effect.
Immunogenetics, Berlin / Heidelberg, February 1983, 17 (2): 141-146.
- Joseph J. Bonner, Michael Melnick:
Current Concepts in Craniofacial Anomalies: A Symposium in Honor of Joseph J. Bonner University of Southern California, August 1-2, 1985.
Book. A.R. Liss, 1986.
- Michael Melnick:
Current Concepts in Craniofacial Anomalies: A Symposium in Honor of Joseph Bonner. John Wiley & Sons Inc, 1986.
- Tina Jaskoll, H. A. Choy, M. Melnick:
Glucocorticoids, TGF-beta, and embryonic mouse salivary gland morphogenesis.
Journal of Craniofacial Genetics and Developmental Biology, 1994, 14: 217-230.
- T. Jaskoll, H.A. Choy, H. Chen, M. melnick:
The CORT-GR signal transduction pathway and CORT-induced cleft palate in H-2 congenic mice. Journal of Craniofacial Genetics and Developmental Biology, April/June 1995, 15 (2): 57-65.
- T. Jaskoll, H. C. Choy, M. Melnick:
The glucocorticoid-glucocorticoid receptor signal transduction pathway, transforming growth factor-beta, and embryonic mouse lung development in vivo.
Pediatric Research, May 1996, 39 (5): 749-759.
- T. Jaskoll, H. Chen, P.C. Denny, P.A. Denny, M. Melnick:
Mouse submandibular gland mucin: embryo-specific mRNA and protein species.
Mechanisms of Development, 1998, 74: 179-183.
- T. Jaskoll, M. Melnick:
Submandibular gland morphogenesis: stage-aspecific expression of TGF-alpha, EGF, IGF, TGF-beta, TNF and IL-6 signal transduction in normal mice and the phenotypic effects of TGF-beta2, TGF-beta3 and EGF-R null mutations.
The Anatomical Record, New York, 1999, 256: 252-268.
- M. Melnick, T. Jaskoll
Mouse submandibular gland morphogenesis: a paradigm for embryonic signal processing.
Critical Reviews in Oral Biology and Medicine, Alexandra, Virginia, 2000, 11:199-215.
- M. Melnick, Haiming Chen, Y. Zhou, T. Jaskoll:
An alternatively spliced Muc10 glycoprotein ligand for putative L-selectin binding during mouse embryonic submandibular gland morphogenesis.
Archives of Oral Biology, Oxford, August 2001, 46: 745-757.
- M. Melnick, H. Chen, Yan-Min Zhou, Tina Jaskoll:
Embryonic mouse submandibular salivary gland morphogenesis and the TNF/TNF-R1 signal transduction pathway.
The Anatomical Record, 2001, 262: 318-320.
- M. Melnick, H. Chen, Y. Min. Zhou, T. Jaskoll
- The functional genomic response of developing embryonic submandibular glands to NF-kappa B inhibition.
BMC Developmental Biology, 2001, 1: 15.
- M. Melnick, H. Chen, Y. Zhou, T. Jaskoll:
Interleukin-6 signaling and embryonic mouse submandibular glands.
Cells Tissues Organs, Basel, 2001, 168: 233-245.
- M Melnick:
Reflections on science II. The language of bioscience.
Clinical Orthodontics and Research, Copenhagen, November 2001, 4: 190-191.
- Tina Jaskoll, Yan-Min Zhou, Yang Chai, Helen P. Makarenkova, J. Martin Collinson, John D. West, Mohammad K. Hajihosseini, Jina Lee, Michael Melnick:
Embryonic submandibular gland morphogenesis: stage-specific protein localization of FGFs, BMPs, Pax6 and Pax9 in normal mice and abnormal SMG phenotypes in FgfR2-IIIc(+/Delta), BMP7(-/-) and Pax6(-/-) mice.
Cells Tissues Organs, 2002, 170: 83-98.
- Michael Melnick
Reflections on science III. A lifetime of looking.
Orthodontics & Craniofacial Research, Oxford, UK, February 2002, 5: 1-2.
- Hua-Wei Chen, Maria Julia Marinissen, Su-Wan Oh, Xiu Chen, Michael Melnick, Norbert Perrimon, J. Silvio Gutkind, Steven X. Hou:
CKA, a novel multidomain protein, regulates the JUN N-terminal kinase signal transduction pathway in Drosophila.
Molecular and Cellular Biology, Washington DC, March 2002, 22: 1792-1803.
- K. Neiswanger, M. E. Cooper, S. M. Weinberg, P. Flodman, A. Bundens Keglovits, Y. Liu, D. N. Hu, M. Melnick, M. A. Spence:
Cleft lip with or without cleft palate and dermatoglyphic asymmetry: evaluation of a Chinese population.
Orthodontics & Craniofacial Research, August 2002, 5: 140-146.
- T. Jaskoll, Y.-M- Zhou, Y. Chai, H.P. Makarenkova, J.M. West, M.K. Hajihosseini, J. Lee, M. Melnick:
Embryonic submandibular gland morphogenesis: stage-specific protein localization of FGFs, BMPs, Pax 6 and Pax 9 and abnormal SMG phenotypes in Fgf/R2-IIIc+/ , BMP7 –/– and Pax 6 –/– mice.
Cells Tissues Organs, 2002, 270: 83-98.
- Tina Jaskoll, Yan-Min Zhou, Gary Trump, Michael Melnick:
Ectodysplasin receptor-mediated signaling is essential for embryonic submandibular salivary gland development.
The Anatomical Record, April 2003, 271: 322-331.
- T. Jaskoll, T. Leo, D. Witcher, M. Ormestad, J. Astorga, Pablo Bringas Jr, P. Carlsson, M. Melnick:
Sonic hedgehog signaling plays an essential role during embryonic salivary gland epithelial branching morphogenesis.
Developmental Dynamics, New York, April 2004, 229: 722-732.
- Tina Jaskoll, Dan Witcher, Leo Toreno, Pablo Bringas, Anne M Moon, Michael Melnick:
FGF8 dose-dependent regulation of embryonic submandibular salivary gland morphogenesis.
Developmental Biology, San Diego, California, April 15, 2004, 268: 457-569.
- T. Jaskoll, M. melnick:
Embryonic salivary gland branching morphogenesis.
In: J. Davies, editor: Branching Morphogenesis. Landes Bioscience, Georgetown, Texas, 2004.
- Katherine Neiswanger, Margaret E. Cooper, You-E Liu, Dan-Ning Hu, Michael Melnick, Seth M. Weinberg, Mary L. Marazita:
Bilateral asymmetry in Chinese families with cleft lip with or without cleft palate.
The Cleft Palate-Craniofacial Journal, Lewiston, NY, March 2005, 42: 192-196.
- Jeonghee Cho, Michael Melnick, Georgios P Solidakis, Philip N Tsichlis:
Tpl2 (tumor progression locus 2) phosphorylation at Thr290 is induced by lipopolysaccharide via an Ikappa-B Kinase-beta-dependent pathway and is required for Tpl2 activation by external signals.
The Journal of Biological Chemistry, Baltimore, May 27, 2005, 280: 20442-20448.
- Tina Jaskoll, George Abichaker, Daniel Witcher, Frederic G Sala, Saverio Bellusci, Mohammad K Hajihosseini:
FGF10/FGFR2b signaling plays essential roles during in vivo embryonic submandibular salivary gland morphogenesis.
BMC Developmental Biology, June 22, 2005, 5: 11.
- Michael Melnick, Daniel Witcher, Pablo Bringas Jr, Peter Carlsson, Tina Jaskoll:
Meckel's cartilage differentiation is dependent on hedgehog signaling.
Cells Tissues Organs, 2005, 179: 146-157.
- Randy Wetzel, Valerie L. Goss, Brett Norris, Lana Popova, Michael Melnick, Bradley L. Smith
Evaluation of CML model cell lines and imatinib mesylate response: determinants of signaling profiles.
Journal of Immunological Methods, Amsterdam, October 20, 2005, 305: 59-66.
- Patrick Bilder, Sandra Lightle, Graeme Bainbridge, Jeffrey Ohren, Barry Finzel, Fang Sun, Susan Holley, Loola Al-Kassim, Cindy Spessard, Michael Melnick, Marcia Newcomer, Grover Waldrop:
The Structure of the Carboxyltransferase Component of Acetyl-CoA Carboxylase Reveals a Zinc-Binding Motif Unique to the Bacterial Enzyme(,).
Biochemistry, Washington, February 14, 2006, 45: 1712-1722.
- Michael Melnick, Anna Petryk, George Abichaker, Dan Witcher, Anthony D. Person, Tina Jaskoll:
Embryonic salivary gland dysmorphogenesis in Twisted gastrulation deficient mice.
Archives of Oral Biology, May 2006, 51 (5): 433-438.
J. V. N. Vara Prasad, Frederick E. Boyer, Lou Chupak, Michael Dermyer, Qizhu Ding, K. Gavardinas, Susan E. Hagen, Michael D. Huband, Wenhua Jiao, Takushi Kaneko, Samarendra N. Maiti, Michael Melnick, Karina Romero, M. Patterson, :
Synthesis and structure-activity studies of novel benzocycloheptanone oxazolidinone antibacterial agents.
Bioorganic & Medicinal Chemistry Letters, Oxford, October 15, 2006, 16 (20): 5392-5397.
- Michael Melnick, Edward Mocarski, George Abichaker, Jing Huang, Tina Jaskoll:
Cytomegalovirus-induced embryopathology: Mouse submandibular salivary gland epithelial-mesenchymal ontogeny as a model.
BMC Developmental Biology, September 7, 2006, 6: 42.
A more comprehensive bibliogarphy will be enetred later.
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