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Friedrich Sigmund Merkel

German anatomist, born April 5, 1845, Nürnberg; died May 28, 1919, Göttingen.




Associated eponyms:
Grandry's corpuscles
Tactile corpuscles that occur in the papillae of the beak and tongue of birds.

Merkel's cell carcinoma
Infrequent but highly aggressive and malignant type of skin cancer.

Merkel's cell-neurite complex
The Merkel cell neurite complex transduces mechanical energy into nerve impulses. This is among the most sensitive vertebrate touch receptors.

Merkel's cells
Touch cells.

Merkel's nerve endings
The tactile nerve endings in the skin.

Merkel's spur
Femoral calcar, Schenkelsporn (German).

Merkel-Ranvier cells
Clear, melanocyte-like cells in the basal layer of the epidermis that contain catecholamine granules.





Biography:
Friedrich Sigmund Merkel was educated in Erlangen, Greifswald, and Göttingen, and obtained his doctorate at Erlangen in 1869. That year he became prosector at the anatomical institute in Erlangen. In 1870 he was habilitated for anatomy and in 1872 accepted an invitation to become ordinarius in Rostock. In 1883 he moved to the same position in Königsberg, and in 1885 to Göttingen.

Merkel wrote a 3 volume book on human anatomy. He experimented with osmium tetroxide staining and described these cells named for him on the skin of a mole and later they were found in human skin.


Bibliography:
  • Die Zona ciliaris. Leipzig, 1870.

  • Die Linea nuchae suprema. Leipzig, 1871.

  • Makroskopische Anatomie des Auges und seiner Umgebungen.
    In Handbuch der Augenheilkunde; Leipzig, 1874.
    2nd edition with Erich Kallius (1867-1935) in 1901.

  • Untersuchungen aus dem anatomischen Institut zu Rostock.
    Rostock, Stiller'schen Hof- und Universitäts-Buchhandlung, 1874. 99 pages.
    First edition. This volume contains the following works by Friedrich Merkel:
    Die trophische Wurzeln des Trigeminus.
    Erstes Entwucklungsstadium der Spermatozoiden.
    Technische Notiz.
    By Bernhard Moritz Carl Ludwig Riedel (1846-1916):
    Entwicklung der Säugethierniere.
    Das Postembryonale Wachstum der Weichtheile.

  • Das Mikroskop und seine Anwendung. München, 1875. XII + 324 pages.

  • Ueber den Bau der Lendenwirbelsäule.
    Archiv für Anatomie und Physiologie, Leipzig, Leipzig, 1877, 1: 314-333

  • Über die Endigungen der sensiblen Nerven in der Haut der Wirbeltiere.
    Rostock, 1880.

  • Handbuch der topographischen Anatomie. Braunschweig 1885-1907.

  • Ergebnisse der Anatomie und Entwickelungsgeschichte.
    From 1892 one annual volume, published with Robert Bonnet (1851-1921)

  • Menschliche Embryonen verschiedenen Alters auf Medianschnitten untersucht. Ein Beitrag zu Mechanik der Entwicklung.
    Göttingen, Dieterich, 1894. 39 pages.
    First edition of the offprint of volume 40 of Abhandlungen der Königlichen Gesellschaft der Wissenschaften in Göttingen.

  • Darmsystem. In Handbuch der Anatomie; volume 6. Jena, 1902.

  • Die Anatomie des Menschen. Mit Hinweisen auf die ärztliche Praxis.
    6 Abteilungen in 11 Bänden. Wiesbaden, J. F. Bergmann, 1913-1918.

  • Anatomische Hefte.
    Works from the anatomical institute, also with Bonnet. Some 30 booklets - or more - appeared, beginning in 1891.

  • Der Schenkelsporn.
    Centralblatt für die medicinischen Wissenschaften, Berlin, 1873, 11 (27): 417-432.

    Biographical:

  • J. Pagel, publisher:
    Biographisches Lexikon hervorragender Ärzte des neunzehnten Jahrhunderts.
    Urban & Schwarzenberg, Berlin and Vienna, 1901.

  • Isidor Fischer, publisher:
    Biographisches Lexikon der hervorragenden Ärzte der letzten fünfzig Jahre.
    Berlin – Wien, Urban & Schwarzenberg, 1932.

  • A. Weissmann, C. Camisa:
    Friedrich Sigmund Merkel. Part I. The man.
    The American Journal of Dermatopathology, New York, 1982, 4 (6): 521-526

  • C. Camisa, A. Weissmann:
    Friedrich Sigmund Merkel. Part II. The cell.
    The American Journal of Dermatopathology, December 1982, 4 (6): 527-535.

  • Barry G. Firkin and Judith A. Whitworth:
    Dictionary of Medical Eponyms.
    The Parthenon Publishing Group. 1989. New edition in 2002.

  • Jeremy M. Norman, editor:
    Morton’s Medical Bibliography. An annotated Check-list of Texts Illustrating the History of Medicine (Garrison and Morton).
    Fifth edition. Scolar Press, 1991.

    List of works in Anatomischer Anzeiger, 1921, 54: 51.

    We thank Rudolf Kleinert, Bad Reichenhall, Germany, for information submitted.


     
 

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