- A dictionary of medical eponyms

Konrad Sandhoff

Born  1939

Related eponyms

German biochemist, born August 11, 1939, Berlin.

Biography of Konrad Sandhoff

Konrad Sandhoff was the son of a chemist with an additional degree in agriculture. He studied chemistry at the Ludwig-Maximilians-Universität in Munich, graduating in 1964. In 1965 he joined the Max-Planck-Institut für Psychiatrie in Munich as a scientific assistant under professor Horst Jatzkewitz. That year he obtained his doctorate with a dissertation entitled "The amaurotic idiocy of man as a derangement of glycosphigolipid metabolism".

At the Max Planck Institute, Sandhoff headed a working group in the department of neurochemistry. He was habilitated as a Privatdozent at Munich in 1972. Until 1979 he worked in research at the Max-Planck-Institute, interrupted by a period as visiting professor at the McCollum-Pratt Institute, Johns Hopkins University, Baltimore, USA (1972-1974), and the Weizman Institute in Rehovel, Israel (1876).

In 1979 he became an unscheduled professor at the University of Munich, but later that year he accepted an invitation as professor of biochemistry in the Kekulé-Institut für Organische Chemie und Biochemie at the Rheinische Friedrich-Wilhelms-Universität Bonn. There he was dean from 1992 to 1994 and 1994 to 1996 deputy dean of the Faculty of Mathematics and Natural Sciences of this university.

Sandhoff's research interests include investigating biochemical and enzymatic aspects of the gangliosidoses and other storage diseases.

Sandhoff has received several scientific awards, among them the Carl-Duisberg Medal from the Gesellschaft Deutscher Chemiker (1976), the Heinrich-Wieland-Preis (1979), and the Richard-Kuhn-Medal from the der Gesellschaft Deutscher Chemiker (1992). In 1998, Sandhoff, then at the Kekulé-Institut für Organische Chemie und Biochemie der Universität Bonn, and Professor Wilhelm Stoffel (born 1928) at the Institut für Biochemie, Universität zu Köln, received the K.J. Zülch-Preis of Gertrud Reemtsma from the Max-Planck-Gesellschaft. The award was given in recognition of their outstanding discoveries in the field of neuro chemistry, discoveries of exceptional importance for the elucidation of inheritable neurological metabolic diseases. In 1999 he received the Max-Planck-Forschungspreis.

From 1992 Sandhoff has been Honorary Member of the American Society for Biochemistry and Molecular Biology, and in 1996 he gave the "Ranwell Caputto Lecture of the Argentine Society for Neurochemistry" in Cordoba. He has been a member of the Leopoldina since 1999. On April 6, 2001, he received the Mendel Medal from the Deutsche Akademie der Naturforscher Leopoldina for his research on inheritable neurological metabolic diseases.


  • R.L. Stevens, A.L. Fluharty, H. Kihara, M.M. Kaback, L.J. Shapiro, B. Marsh, K. Sandhoff, G. Fischer:
    Cerebroside sulfatase activator deficiency induced metachromatic leukodystrophy.
    The American Journal of Human Gentics, November 1981, 33 (6): 900-906.
  • K. Sandhoff, T. Kolter:
    Topology of glycosphingolipid degradation.
    Trends in Cell Biology, Cambridge, 1995, 6: 98-103.
  • S. Arnis, S. Ilangumaran, G. van Echten-Deckert, K. Sandhoff, M. Poincelet, A. Briol, E. Runager-Brändle, D. Hoessli:
    Differential regulation of Src-family protein tyrosine kinases in GPI domains of T lymphocyte plasma membranes.
    Biochemical and Biophysical Research Communications, New York, August 23, 1996, 225 (3): 801-807.
  • S. Akli, J. Guidotti, E. Vigne, M. Perricaudet, K. Sandhoff, A. Kahn:
    Restoration of hexosaminidase A activity in human Tay-Sachs fibroblasts via adenoviral vector-mediated gene transfer.
    Gene Therapy, Basingstoke, UK, September 1996, 3 (9): 769-774.
  • M. Henseler, A. Klein, M. Reber, T. Vanier, P. Landrieu, K. Sandhoff:
    Analysis of a splice-site mutation in the SAP-precursor gene of a patient with metachromatic leukodystrophy.
    The American Journal of Human Gentics, Chicago, 1996, 58: 65-74.
  • M. Henseler, K. Harzer, K. Sandhoff:
    Sphingolipid Activator Protein.
    In: The Metabolic and Molecular Bases of Inherited Disease.
    CD-Rom, eds. Scriver, N.Y., Addendum Chapter 76, 1996.
  • T. Kolter, K. Sandhoff:
    Inhibitors of glycosphingolipid biosynthesis.
    Chemical Society Reviews, London, 1996, 25: 371-381.
  • M. Pennybacker, B. Liessem, H. Moczall, C. Tifft, K. Sandhoff, R. Proia:
    Identification of domains in human -hexosaminidase that determine substrate specificity.
    The Journal of Biological Chemistry, 1996, 271: 17377-17382
  • G. Vielhaber, R. Hurwitz, K. Sandhoff:
    Biosynthesis, processing and targeting of sphingolipid activator protein (SAP) precursor in cultured human fibroblasts - Mannose 6-phosphate receptor-independent endocytosis of SAP precursor.
    The Journal of Biological Chemistry, 1996, 271 (50), 32438-32446.
  • J. Koch, S. Gärtner, C. Li, L. Quintern, K. Bernardo, O. Levran, D. Schnabel, R. Desnick, E. Schuchman, K. Sandhoff:
    Molecular cloning and characterization of a full-length complementary DNA encoding human acid ceramidase - Identification of the first molecular lesion causing Farber disease.
    The Journal of Biological Chemistry, 1996, 271, 33110-33115.
  • R. Kase, U. Bierfreund, A. Klein, T. Kolter, K. Itoh, M. Suzuki, Y. Hashimoto, K. Sandhoff, H. Sakuraba:
    Only sphingolipid activator protein in B (SAP-B or saposin B) stimulates the degradation of globotriaosylceramide by recombinant human lsysosomal - galactosidase in a detergent-free liposomal system.
    FEBS Letters, 1996, 393: 74-76.
  • S. Lansmann, K. Ferlinz, R. Hurwitz, G. Glombitza, K. Sandhoff:
    Purification of the acid sphingomyelinase from human placenta: Chracterization and N-terminal sequence.
    FEBS Letters, 1996, 399: 227-231.
  • E. Müller, A. Giehl, G. Schwarzmann, K. Sandhoff, A. Blume:
    Oriented 1,2-Dimyristoyl-sn-glycero-3-phosphorylcholine/ganglioside membranes: A fourier transform infrared attenuated total reflection spectroscopic study. Band assignments; orientational, hydrational, and phase behaviour; and effects of Ca2+ binding.
    Biophysical Journal, Bethesda, Maryland, 1996, 71: 1400-11421.
  • A. Schick, T. Kolter, A. Giannis, K. Sandhoff:
    Synthesis of phosphoramide analogues of sphinganine-1-phosphate.
    Tetrahedron, 1996, 52: 2495-2956.
  • U. Schepers, G. Glombitza, T. Lemm, A. Hoffmann, A. Chabas, P. Ozand, K. Sandhoff:
    Molecular analysis of a GM2-activator deficiency in two patients with GM2-gangliosidosis AB variant.
    The American Journal of Human Gentics, Chicago, 1996, 59: 1048-1056.
  • K. Sango, M. McDonald, J. Crawley, M. Mack, C. Tifft, E. Skop, C. Starr, A. Hoffmann, K. Sandhoff, K. Suzuki, R. Proia:
    Mice lacking both subunits of lysosomal -hexosamidase diplay gangliosidosis and mucolipidosis.
    Nature Genetics, New York, 1996, 14: 348-352.
  • C. Zacharias, G. van Echten-Deckert, E. Wand E, Alfred H. Merrill Jr, K. Sandhoff:
    The effect of fumosin B1 on developing chick embryos: correlation between de novo sphingolipid biosynthesis and gross morphological changes.
    Glycoconjugate Journal, 1996, 13, 167-175.
  • K. Sandhoff:
    Glykolipide der Zelloberfläche und die Pathobiochemie der Zelle. In Vorträge N 422 Nordrhein-Westfälische Akademie der Wissenschaften, 402. Sitzung am 1. Juli 1994 in Düsseldorf. Westdeutscher Verlag, 1996.
  • J. Burkhardt, S. Hüttler, A. Klein, W. Möbius, A. Habermann, G. Griffiths, K. Sandhoff:
    Accumulation of sphingolipids in SAP-precursor (prosaposin) deficient fibroblasts occurs within lysosomes and can be completely reversed by treatment with human SAP precursor.
    European Journal of Cell Biology, Stuttgart, 1997, 73, 10-18.
  • B. Albrecht, G. Pohlentz, K. Sandhoff, G. Schwarzmann:
    Synthesis and mass spectrometric characterization of digoxingenin and biotin labeled ganglioside GM1 and their uptake by and metabolism in cultured cells.
    Chemistry and Physics of Lipids, Limerick, 1997, 86: 37-50.
  • H. Grassme, A. Gulbins, B. Brenner, K. Ferlinz, K. Sandhoff, K. Harzer, F. Lang, T. Meyer:
    Acid sphingomyelinase mediates entry of N. gonorrhoeae into non-phagocytic cells.
    Cell,. Cambridge, Massachusetts, 1997, 91: 605-606.
  • T. Kolter, K. Sandhoff:
    Sialic acids - why always a-linked?.
    Glycobiology, Glyco-Forum section 7, VII-X, 1997
  • C. Michel, G. van Echten-Deckert, J. Rother, K. Sandhoff, E. Wang, A. Merrill:
    Characterization of ceramide synthesis - A dihydroceramide desaturase introduces the 4,5-trans-double bond of sphingosine at the level of dihydroceramide.
    The Journal of Biological Chemistry, 1997, 272: 22432-22437.
  • Y. Liu, A. Hoffmann, A. Grinberg, H. Westphal, M. McDonald, K. Miller, J. Crawley, K. Sandhoff, K. Suzuki, R. Proia:
    Mouse model of GM2 activator deficiency manifests cerebellar pathology and motor impairment.
    Proceedings of the National Academy of Sciences of the United States of America, Washington DC, 1997, 94: 8138-8143.
  • G. Glombitza, E. Becker, H. Kaiser, K. Sandhoff:
    Biosynthesis, processing and intracellular transport of GM2 activator protein in human epidermal keratinozytes: the lysosomal targeting of the GM2 activator is independent of a mannose-6-phosphate signal.
    The Journal of Biological Chemistry, 1997, 272: 5199-5207.
  • M. Pennybacker, C. Schuette, B. Liessem, S. Hepbildikler, J. Kopetka, M. Ellis, R. Myerowitz, K. Sandhoff, R. Proia:
    Evidence for the involvement of Glu-355 in the catalytic action of human -hexosaminidase B. The Journal of Biological Chemistry, 1997, 272: 8002-8006.
  • G. van Echten-Deckert, A. Zschoche, T. Baer, R. Schmidt, A. Raths, T. Heinemann, K. Sandhoff:
    cis-4-Methylsphingosine decreases sphingolipid biosynthesis by specifically interfering with serine palmitoyltransferase activity in primary cultured neurons.
    The Journal of Biological Chemistry, 1997, 272: 15825-15833.
  • K. Sandhoff, T. Kolter:
    Biochemistry of glycosphingolipid degradation.
    Clinica chimica acta, Amsterdam, 1997, 266: 51-61.
  • G. van Echten-Deckert, A. Klein, T. Linke, T. Heinemann, J. Weisgerber, K. Sandhoff:
    Turnover of endogenous ceramide in cultured normal and Farber fibroblasts.
    Journal of Lipid Research, Bethesda, 1997, 38:12, 2569-2579.
  • A. Schick, G. Schwarzmann, T. Kolter, K. Sandhoff:
    Synthesis of tritium in labelled phosphate analogues of sphinganine-1-phosphate.
    Journal of Labelled Compounds and Radiopharmaceuticals, 1997, 39: 441-451.
  • T. Wieder, C. Geilen, T. Kolter, F. Sadeghlar, K. Sandhoff, R. Brossmer, P. Ihrig, D. Perry, C. Ofanos, Y. Hannun:
    Bcl-2 antagonizes apototic cell death induced by two new ceramide analogues.
    FEBS Letters, 1997, 411, 260-264.
  • M. Bektas, Y. Dullin, T. Wieder, T. Kolter, K. Sandhoff, R. Brossmer, P. Ihrig, C. Orfanos, C. Geilen:
    Induction of apoptosis by synthetic ceramide analogues in the human keratinocyte cell line HaCaT. Experimental Dermatology, Copenhagen, 1998, 7: 342-349.
  • O. Bartelsen, S. Lansmann, M. Nettersheim, T. Lemm, K. Ferlinz, K. Sandhoff:
    Expression of recombinant human acid sphingomyelinase in insect Sf21 cells: Purification, processing and enzymatic characterization. Journal of Biotechnology. Amsterdam, 1998, 63: 29-40.
  • K. Breen, A. Potratz, N. Georgopoulou, K. Sandhoff:
    The generation and characterization of a rat neural cell line overexpression the a2,6(N)sialyltransferase.
    Glycoconjugate Journal, London, 1998, 15: 199-202.
  • U. Bierfreund, T. Lemm, A. Hoffmann, G. Uhlhorn-Dierks, R. Childs, C. Yuen, T. Feizi, K. Sandhoff:
    Recombinant GM2-activator protein stimulates in vivo degradation of GA2 in GM2 gangliosidosis AB variant fibroblasts but exhibits no detectable binding of GA2 in an in vitro assay.
    Neurochemical Research, New York, 1998, 24, 295-300.
  • B. Brenner, K. Ferlinz, H. Grassme, M. Weller, U. Koppenhoefer, J. Dichgans, K. Sandhoff, F. Lang, E. Gulbins:
    Fas/CD95/Apo-I activates the acidic sphingomyelinase via caspases.
    Cell Death and Differentiation, 1998, 5: 1, 29-37.
  • T. Hiesberger, S. Huettler, A. Rohlmann, W. Schneider, K. Sandhoff, J. Herz:
    Cellular uptake of saposin (SAP) precursor and lysosomal delivery by the low density lipoprotein receptor-related protein (LRP).
    EMBO Journal, 1998, 17: 4617-4625.
  • P. Landrieu, S. Blanche, M. Vanier, S. Metral, B. Husson, K. Sandhoff, A. Fischer:
    Bone marrow transplantation in metachromatic leukodystrophy caused by saposin-B deficiency: A case report with a 3-year follow-up period.
    The Journal of Pediatrics, St. Louis, M0, 1998, 133: 129-132.
  • T. Kolter, K. Sandhoff:
    Structure, function and metabolism.
    Glycobiology Catalog 1998 (Calbiochem) 132-133, 1998.
  • T. Kolter, K. Sandhoff:
    Recent advances in the biochemistry of sphingolipidoses.
    Brain Pathology, 1998, 8: 79-100.
  • T. Kolter, K. Sandhoff:
    Glycosphingolipid degradation and animal models of GM2-gangliosidoses.
    Journal of Inherited Metabolic Disease, Dordrecht, 1998, 21: 548-563.
  • C. Li, S. Hong, G. Kopal, X. He, T. Linke, W. Hou, J. Koch, S. Gatt, K. Sandhoff, E. Schuchman:
    Cloning and characterization of the full-length cDNA and genomic sequences encoding murine acid ceramidase - Analysis of mRNA and enzymatic expression in adult mice.
    Genomics, San Diego, California, 1998, 50: 267-274.
  • F. Norflus, C. Tifft, M. McDonald, G. Goldstein, J. Crawley, A. Hoffmann, K. Sandhoff, L. Suzuki, R. Proia:
    Bone marrow transplantation prolongs life span and ameliorates neurologic manifestations in Sandhoff disease mice.
    The Journal of Clinical Investigation, Ann Arbor, MI, 1998, 101: 1881-1888.
  • K. Sandhoff, T. Kolter, G. van Echten-Deckert:
    Sphingolipid activator proteins and the pathology of the cells.
    In: Robert W. Ledeen, Sen-Itoroh Hakamori, Allan J. Yates, Jay S. Schneider, Robert K. Yu, editors: Sphingolipids as Signaling Modulators in the Nervous System.
    New York Academy of Sciences, Annals. 1998, 845: 139-151.
  • K. Sandhoff, T. Kolter:
    Processing of sphingolipid activator proteins and the topology of lysosomal digestion.
    Acta biochimica Polonica, Warsaw, 1998, 45: 373-384.

  • K. Sandhoff, T. Kolter:
    Glycolipid enzymology at membrane surfaces, Trends Glycosci. Glycotechnd.
    TIGG 10, No. 56, 1998
  • K. Sandhoff:
    Hemmnisse universitaerer Forschung. In: Zwei Jahrhunderte Wissenschaft und Forschung in Deutschland - Entwicklungen - Perspektiven (Symposium aus Anlass des 175jährigen Bestehens der Gesellschaft Deutscher Naturforscher und AErzte (GDNAE) 19. - 20. September 1997 in Luebeck.
    Wissenschaftliche Verlagsgesellschaft mbH Stuttgart, 256 - 259, 1998

  • G. van Echten-Deckert, A. Giannis, A. Schwarz, A. Futerman, K. Sandhoff:
    1-Methylthiodihydroceramide, a novel analog of dihydroceramide, stimulates sphinganine degradation resulting in decreased de novo sphingolipid biosynthesis.
    The Journal of Biological Chemistry, 1998, 273: 1184-1191.
  • G. Uhlhorn-Dierks, T. Kolter, K. Sandhoff:
    Wie werden Schwefelsaeureester in der Natur gespalten? Eine neuartige posttranslationale Proteinmodifikation bei Sulfatasen.
    Angewandte Chemie, Weinheim, 1998: 2591-2594.
  • C. Schuette, T. Lemm, G. Glombitza, K. Sandhoff:
    Complete localization of disulfide bonds in GM2 activator protein.
    Protein Science, 1998, 7: 1039-1045.

  • G. Wilkening, T. Linke, K. Sandhoff:
    Lysosomal degradation on vesicular membrane surfaces: Enhanced glucosylceramide degradation by lysosomal anionic lipids and activators.
    The Journal of Biological Chemistry, 1998, 273, 30271-30278.
  • S. Natzker, T. Heinemann, S. Figueroa-Perez, B. Schnieders, R.R. Schmidt, K. Sandhoff, G. van Echten-Deckert:
    Cis-4-methylsphingosine phosphate induces apoptosis in neuroblastoma cells by opposite effects on p38 and ERK mitogen-activated protein kinases.
    Biological Chemistry, Berlin, December 2002, 383 (12):1885-1894.
  • L. Elsen, R. Betz, G. Schwarzmann, K. Sandhoff, G. van Echten-Deckert:
    Identification of ceramide binding proteins in neuronal cells: a critical point of view.
    Neurochemical Research, New York, August 2002, 27 (7-8): 717-727.
  • R. Betz, K. Sandhoff, K.D. Fischer, G. van Echten-Deckert:
    Detection and identification of Vav1 protein in primary cultured murine cerebellar neurons and in neuroblastoma cells (SH-SY5Y and Neuro-2a).
    Neuroscience Letters, Limerik, March 13, 2003, 339 (1): 37-40.
  • R. Buccoliero, J. Bodennec, G. Van Echten-Deckert, K. Sandhoff, A.H. Futerman:
    Phospholipid synthesis is decreased in neuronal tissue in a mouse model of Sandhoff disease. Journal of Neurochemistry, July 2004, 90 (1): 80-88.
  • S. Koochekpour, O. Sartor, T.J. Lee, A. Zieske, D.Y. Patten, M. Hiraiwa, K. Sandhoff, N. Remmel, A. Minokadeh:
    Prosaptide TX14A stimulates growth, migration, and invasion and activates the Raf-MEK-ERK-RSK-Elk-1 signaling pathway in prostate cancer cells.
    The Prostate, New York, October 1, 2004, 61 (2): 114-123.
  • M.M. Gopalakrishnan, H.W. Grosch, S. Locatelli-Hoops, N. Werth, E. Smolenova, M. Nettersheim, K. Sandhoff, A. Hasilik:
    Purified recombinant human prosaposin forms oligomers that bind procathepsin D and affect its autoactivation.
    The Biochemical Journal, London, November 1, 2005, 383 (Pt. 3): 507-515.
  • J. Reichelt, B. Breiden, K. Sandhoff. T.M. Magin:
    Loss of keratin 10 is accompanied by increased sebocyte proliferation and differentiation.
    European Journal of Cell Biology, Stuttgart December 2004, 83 (11-12): 747-759.
  • H. Gallala, O. Macheleidt, T. Doering, V. Schreiner, K. Sandhoff:
    Nitric oxide regulates synthesis of gene products involved in keratinocyte differentiation and ceramide metabolism.
    European Journal of Cell Biology, December 2004, 83 (11-12): 667-679.
  • M. Kolzer, K. Ferlinz, O. Bartelsen, S.L. Hoops, F. Lang, K. Sandhoff:
    Functional characterization of the postulated intramolecular sphingolipid activator protein domain of human acid sphingomyelinase.
    Biological Chemistry, Berlin, December 2004, 385 (12): 1193-1195.
  • U.H. Schueler, T. Kolter, C.R. Kaneski, G.C. Zirzow, K. Sandhoff, R.O. Brady:
    Correlation between enzyme activity and substrate storage in a cell culture model system for Gaucher disease.
    Journal of Inherited Metabolic Disease, Dordrecht, 2004, 27 (5): 649-658.
  • P. Sawatzki, I. Damm, B. Pierstorff, H. Hupfer, K. Sandhoff, T. Kolter:
    Site-specific cleavage--a model system for the identification of lipid-modified glutamate residues in proteins.
    Chembiochem, January 2005, 6 (1): 178-185.
  • T. Yamashita, Y.P. Wu, R. Sandhoff, N. Werth, H. Mizukami, J.M. Ellis, J.L. Dupree, R. Geyer, K. Sandhoff, R.L. Proia:
    Interruption of ganglioside synthesis produces central nervous system degeneration and altered axon-glial interactions.
    Proceedings of the National Academy of Sciences of the United States of America, Washington DC, February 22, 2005, 102 (8): 2725-2730.
  • J.A. Chavez, W.L. Holland, J. Bar, K. Sandhoff, S.A. Summers:
    Acid ceramidase overexpression prevents the inhibitory effects of saturated fatty acids on insulin signaling.
    The Journal of Biological Chemistry, May 20, 2005, 280 (20):20148-20153.
  • T. Kolter, K. Sandhoff:
    Principles of Lysosomal Membrane Digestion-Stimulation of Sphingolipid Degradation by Sphingolipid Activator Proteins and Anionic Lysosomal Lipids.
    Annual Review of Cell and Developmental Biology, May 16, 2005.
  • S. Koochekpour, O. Sartor, M. Hiraiwa, T.J. Lee, W. Rayford, N. Remmel, K. Sandhoff, A. Minokadeh, D.Y. Patten:
    Saposin C stimulates growth and invasion, activates p42/44 and SAPK/JNK signaling pathways of MAPK and upregulates uPA/uPAR expression in prostate cancer and stromal cells.
    Asian Journal of Andrology, Shanghai, June 2005, 7 (2): 147-158.
  • I.Y. Tamboli, K. Prager, E. Barth, M. Heneka, K. Sandhoff, J. Walter:
    Inhibition of glycosphingolipid biosynthesis reduces secretion of the beta-amyloid precursor protein and amyloid beta-peptide.
    The Journal of Biological Chemistry, July 29, 2005, 280 (30): 28110-28117.
  • G. Schwarzmann, M. Wendeler, K. Sandhoff:
    Synthesis of novel NBD-GM1 and NBD-GM2 for the Transfer-Activity of GM2-Activator Protein by a FRET-based Assay System.
    Glycobiology, Oxford, August 3, 2005.
  • C. Leyvraz, R.P. Charles, I. Rubera, M. Guitard, S. Rotman, B. Breiden, K. Sandhoff, E. Hummler:
    The epidermal barrier function is dependent on the serine protease CAP1/Prss8.
    The Journal of Cell Biology, New York, August 1, 2005, 170 (3): 487-496.
  • S. Martino, P. Marconi, B. Tancini, D. Dolcetta, M.G. De Angelis, P. Montanucci, G. Bregola, K. Sandhoff, C. Bordignon, C. Emiliani, R. Manservigi, A. Orlacchio:
    A direct gene transfer strategy via brain internal capsule reverses the biochemical defect in Tay-Sachs disease.
    Human Molecular Genetics, August 1, 2005, 14 (15): 2113-2123.
  • A. J. Norris, J.P. Whitelegge, A. Yaghoubian, J.R. Alattia, G.G. Prive, T. Toyokuni, H. Sun, M.N. Brooks, L. Panza, P. Matto, F. Compostella, N. Remmel, R. Klingenstein, K. Sandhoff, C. Fluharty, A. Fluharty, K.F. Faull:
    A novel mass spectrometric assay for the cerebroside sulfate activator protein (saposin B) and arylsulfatase A.
    Journal of Lipid Research, October 2005, 46 (10): 2254-2264.
  • T. Kolter, K. Sandhoff:
    Principles of lysosomal membrane digestion: Stimulation of Sphingolipid Degradation by Sphingolipid Activator Proteins and Anionic Lysosomal Lipids.
    Annual Review of Cell and Developmental Biology, Palo Alto, November 10, 2005, 21: 81-103.
  • S. Koochekpour, Y. J. Zhuang, R. Beroukhim, C. L. Hsieh, M. D. Hofer, H. E. Zhau, M. Hiraiwa, D. Y. Pattan, J. L. Ware, R. B. Luftig RB, K. Sandhoff, C. L. Sawyers, K. J. Pienta, M. A. Rubin, R. L. Vessella, W. R. Sellers, O. Sartor:
    Amplification and overexpression of prosaposin in prostate cancer.
    Genes, Chromosomes & Cancer, New York, December 2005, 44 (4): 351-364.
  • H. Pavlu-Pereira, B. Asfaw, H. Poupctova, J. Ledvinova, J. Sikora, M.T. Vanier, K. Sandhoff, J. Zeman, Z. Novotna, D. Chudoba, M. Elleder:
    Acid sphingomyelinase deficiency. Phenotype variability with prevalence of intermediate phenotype in a series of twenty-five Czech and Slovak patients. A multi-approach study.
    Journal of Inherited Metabolic Disease, Dordrecht, 2005, 28 (2): 203-227.

What is an eponym?

An eponym is a word derived from the name of a person, whether real or fictional. A medical eponym is thus any word related to medicine, whose name is derived from a person.

What is Whonamedit?

Whonamedit.com is a biographical dictionary of medical eponyms. It is our ambition to present a complete survey of all medical phenomena named for a person, with a biography of that person.


Whonamedit? does not give medical advice.
This survey of medical eponyms and the persons behind them is meant as a general interest site only. No information found here must under any circumstances be used for medical purposes, diagnostically, therapeutically or otherwise. If you, or anybody close to you, is affected, or believe to be affected, by any condition mentioned here: see a doctor.