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Edward Francis
American bacteriologist, born March 27, 1872, Shandon, Ohio; died 1957.
Associated eponyms:
Francis' disease
An infectious, plague like, zoonotic disease caused by infection with the bacillus Francisella tularensis. It is found primarily in rodents but also affects humans and many other animals.
Francisella novicida
The etiologic agent of a disease resembling tularaemia in guinea pigs, hamsters, and white mice; not known to infect man.
Francisella tularensis
The causative agent of tularaemia.
Biography:
Edward Francis studied at the Ohio State University and at the University of Cincinnati, where he received his medical degree in 1897. In 1900 he was appointed Officer of the United States Public Health Service, Washington, subsequently working there as bacteriologist at the hygienical laboratory. He was appointed Medical Director in 1930 and retired January 1, 1938.
Francis contracted tularaemia from the first “deer fly fever” patient he visited in Utah. During three months of sickness he kept a careful record of his illness.
He discovered that one attack confers permanent immunity in man. He was continuously exposed to Bacterium tularense for sixteen years, accidentally reinfecting himself on four occasions. He proved conclusively that local reinfection in a tularaemia-immune individual is an immune reaction, as in revaccination with smallpox vaccine virus.
In 1928 the American Medical Association awarded Francis its Gold Medal for his contributions to the knowledge of tularaemia. He received honorary degrees from Miami University and Ohio State University. Besides tularaemia, Francis also wrote on yellow fever, pellagra, tetanus, filariasis and febris undulans.
Bibliography:
- Deer-fly fever, or Pahvant Valley plague; a disease of man of hitherto unknown etiology.
Public Health Reports, 1919, 34: 2061-2062.
- Tularaemia Francis 1921. The occurrence of tularemia in nature as a disease of man. Public Health Reports, 1921, 36: 1731-1753.
- Cultivation of Bacterium tularense on mediums new to this organism.
Public Health Reports, 1922, 27: 102-115.
- Tularemia Francis 1921: a new disease of man.
Washington, Government Printing Office, 1922.
(Hygienic Laboratory Bulletin no, 130) 87 pages.
- Cultivation of Bacterium tularense on three additional mediums new to this organism. Public Health Reports, 1922, 37: 987-989, 1922.
- Tularemia. Journal of the American Medical Association, 1925, 84: 1243-1250.
- A summary of the present knowledge of tularemia.
Medicine, Baltimore, 1929, 7: 411 432.
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