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Alfred Wolff-Eisner
German physician, born August 25, 1877, Berlin; died 1948.
Associated eponyms:
Calmette and Wolff-Eisner ophthalmo reaction
A particular form of tuberculine reaction provoking a conjunctivitis of the eye.
Biography:
Alfred Wolff-Eisner studied at Berlin as well as at Kiel and Tübingen, where he obtained his doctorate in 1901. He spent his internship and assistant period at the Berlin city hospitals under Moritz Litten (1845-1907) and Johannes Karl August Eugen Alfred Goldscheider (1858-1935), at the Königsberg hygienic institute under Richard Friedrich Johannes Pfeiffer (1858-1945), and at the Berlin university policlinic under Hermann Senator (1834-1911). He was habilitated for internal medicine in 1923, becoming ausserordentlicher professor in 1928.
Wolf-Eisner’s work concerns haematology, immunity research; internal medicine, particularly tuberculosis, and diseases of hypersensitivity.
Bibliography:
With Martin Klimmer (1873-1943) he published:
- Handbuch der Serumtherapie und Serumdiagnostik in der Veterinärmedizin. 2 volumes, Leipzig, 1911.
Alone he published:
- Handbuch der experimentellen Therapie, Serum- und Chemotherapie.
Munich, 1912; 2nd edition, 1926; supplementary volume, 1931.
Works:
- Ueber eine Methode zur Untersuchung des lebenden Knochenmarks von Thieren und über das Bewegungsvermögen der Myelocyten.
Deutsche medizinische Wochenschrift, 1903, 29: 165-167.
Wolff-Eisner trephined the tibia and femur of experimental animals and suggested biopsy of bone marrow as a clinical procedure.
- Das Heufieber, sein Wesen and seine Behandlung.
München, 1906. Translated into Spanish.
Wolff-Eisner coined the terms pollen disease and pollen sensitivity. He suggested that hay-fever might be a form of hypersensitivity or anaphylaxis in the nose and four years later Samuel James Meltzer (1851-1920) made a similar suggestion for asthma.
- Die Ophthalmo- und Kutan-Diagnose der Tuberkulose. Würzburg, 1908.
- Frühdiagnose und Tuberkulose-Immunität.
Würzburg, 1909. Translated into Russian.
- Klinische Immunitätslehre und Serodiagnostik. Jena, 1910.
- Handbuch der experimentellen Serumtherapie. München, J. F. Lehmann, 1910.
- Die Prognosen-Stellung bei der Lungentuberkulose.
With Desider von Kuthy-Okolicsányi (1869-1947). Hungarian: Dezső Okolicsányi-Kuthy. Berlin and Vienna, 1914.
- Tuberkulose-Diagnostik und -Therapie. Leipzig, 1921.
- Die Gerson Sauerbruch Tuberkulose Diät im Urteil der Fachkritik.
Beiträge zur Klinik der Tuberkulose, 1930, 73: 829-834.
- P. Voswinckel:
Grabstein vor dem Verfall bewahrt. In memoriam Professor Alfred Wolff-Eisner (1877-1948), jüdischer Pionier der Pollenkrankheit.
Allergologie, 1988, 11: 41-46. We thank Patrick Jucker-Kupper, Switzerland, for information submitted.
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