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Daniel Alagille
French paediatrician, born January 24, 1925, Paris.
Associated eponyms:
Alagille's syndrome
A congenital familial syndrome marked by clinical picture with intrahepatic cholestasis, neonatal jaundice, and hepatomegaly.
Biography:
Daniel Alagille in 1954 graduated from the University of Paris, where he also obtained a diploma in biochemistry. From 1954 to 1964 he worked in the Hôpial Saint-Vincent-de Paul and was appointed associate professor in 1963. He as elevated to full professor of paediatrics and clinical genetics at the Université Paris-Sud in 1971, also being staff physician and chairman of the department of paediatrics, Hôpital de Bicêtre, where he founded a paediatric liver unit. From 1964 he was chief of the paediatric liver research unit of the Institut National de la Santé et de la Recherche. He remained with the Hôpital de Bicêtre until his retirement in 1990.
Alagille was chief editor of the Revue internationale d'hépatologie (1954-1971) and Archives françaises de pédiatrie (1964-1990). He has published more than 500 articles and several books. He became Chevalier de l'Ordre National du Mérite in 1967 and Chevalier de la Légion d'Honneur in 1988. By 1996 he was professor emeritus at the Université Paris-Sud in Bicêtre.
Bibliography:
- D. Alagille, E. C. Habib, N. Thomasin:
L'atrésie des voies biliaires intra-hépatiques avec voies biliaires extra-hépatiques perméables chez l'enfant (à propos de 25 observations).
In: Pierre Royer, editor, Journées parisiennes de pédiatrie. Paris: Flammarion, 1969: 301-18.
- D. Alagille, M. Odièvre, M. Gautier, J. P. Dommergues:
Hepatic ductular hypoplasia associated with characteristic facies, vertebral malformations, retarded physical, mental, and sexual development, and cardiac murmur.
Journal of Pediatrics, St. Louis, 1975, 86: 63-71.
- D. Alagille, A. Estrada, M. Hadchouel, M. Gautier, M. Odièvre, J. P. Dommergues:
Syndromic paucity of interlobular bile ducts (Alagille syndrome or arteriohepatic dysplasia): review of 80 cases.
Journal of Pediatrics, St. Louis, 1987, 110: 195-200.
- F. R. Zhang, J. F. Deleuze, A. Aurias, A. M. Dutrillaux, R. N. Hugon RN, D. Alagille, et al:
Interstitial deletion of the short arm of chromosome 20 in arteriohepatic dysplasia (Alagille syndrome).
Journal of Pediatrics, St. Louis, 1990, 116: 73-7.
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