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Alexis Joffroy
French physician and neuropsychiatrist, born December 16, 1844, Stainville, Meuse; died November 24, 1908
Associated eponyms:
Joffroy's reflex
Gluteal phenomenon in ischias.
Joffroy's sign I
Sign for exophthalmic goiter; Basedowoid eye symptom.
Joffroy's sign II
Cessation of twitch in chorea electrica when there is pressure on the n. facialis.
Joffroy's sign III
Lacking ability to make simple arithmetic sum up. An early sign in lunatics, caused by syphilis in the central nervous system.
Spiller's syndrome
A syndrome characterized by sensory disturbances, localized or diffuse pain in the back, chest, or legs, which may be followed by symptomatic weakness in the knees, and transverse myelitis.
Biography:
Alexis Joffroy studied in Paris, where Jean-martin Charcot (1825-1893) influenced him to devote his efforts to neurology. He obtained his doctorate in Paris in 1873, was appointed médecin des hôpitaux in 1879, and the following year became agrégé at the Paris faculty. He came to the Salpêtrière in 1885, and from 1893 to his death in 1908 was professor of clinical psychiatry, teaching at the Asile St.-Anne.
Alexis Joffroy made contributions to the understanding of syringomyelia. In 1869 Joffroy and Charcot demonstrated the atrophy of the anterior horn cells of the spinal cord in poliomyelitis.
Of particular interest are his investigations on the etiological influence of alcohol on progressive paralysis.
Bibliography:
- De la pachyméningite cervicale hypertrophique. Paris, 1873.
- De la médication par l' alcool. Paris, 1875.
- De l’influence des excitations cutanées sur la circulation et la calorification. Paris, 1878.
- Des différentes formes de la broncho-pneumonie. Paris, 1880.
- Nature et traitement de goître exophtalmique. Paris, 1894.
- Fugres et vagabondage. With R. Dupouy. Paris, 1909.
- La paralysie générale. With Mignot. Paris, 1909.
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